Flights from Gainesville to Knoxville – Direct & connecting routes
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GNV to TYS – All flight route options from Gainesville Rgnl, Florida, USA to Mc Ghee Tyson, Tennessee, USA. These flights are operated by 2 airlines. Fly non-stop with Delta Air Lines or choose from 2 different transit flights. The shortest flight time is 1 hour and 20 minutes. See the full flight schedule and time table, including departure times, airlines and stopover details to find the best option for you.
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Gainesville to Knoxville flights
With over 57 flights every week and 3 different airlines you have a wide range of options. You can fly non-stop to Knoxville (TYS) from Gainesville (GNV) with Delta Air Lines or choose a connecting flight via Charlotte (CLT) or Atlanta (ATL) if it suits you better.
Gainesville to Knoxville with Delta Air Lines
You can fly non-stop with Delta Air Lines every Sunday at 11:10. You also have the option to do a transit flight via Atlanta. Delta Air Lines is a member of SkyTeam.
Note Non-stop flights with Delta Air Lines will begin in Nov 2025.
With American Airlines
If you fly from Gainesville with American Airlines you will do a stopover in Charlotte, CLT before reaching Knoxville. This flight trip will take 4 hours and 13 minutes and you can fly every weekday with departures from 6:00 am to 8:00 pm. American Airlines is a member of the air alliance OneWorld.
Distance & flight times: Gainesville Rgnl to Mc Ghee Tyson
The shortest flight time between GNV and TYS is 1 hour and 20 minutes.
Via | Total flight time | Layover time | Distance |
---|---|---|---|
Direct | 1h 20m | - | 436 miles (702 km) |
CLT Charlotte | 4h 13m | 2h 41m | 569 miles (916 km) |
ATL Atlanta | 4h 22m | 2h 18m | 454 miles (730 km) |

