Flights from Mexico City to Santiago – Direct & connecting routes
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MEX to SCL – All flight route options from Mexico City International Airport, Mexico to Arturo Merino Benítez International Airport, Chile. These routes are operated by 5 airlines. Fly non-stop with LATAM Airlines or Aeromexico, or choose from 5 different stopover flights. The shortest flight time is 8 hours and 5 minutes. See the full flight schedule and time table, including departure times, airlines and stopover details to find the best option for you.
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Mexico City to Santiago flights
With over 110 flights every week and 7 different airlines you have a wide range of options. You can fly non-stop to Santiago (SCL) from Mexico City (MEX) with Aeromexico or LATAM Airlines but if a stopover option suits you better you can choose to fly via Lima, Bogota or any other of the 5 alternatives with connectiing airports.
Mexico City to Santiago with Aeromexico
You can fly non-stop every weekday with flights departing at 10:00, 10:05 or 10:10. Aeromexico is a member of SkyTeam.
Note Non-stop flights with Aeromexico will begin in Oct 2025.
With LATAM Airlines
You can fly non-stop every weekday with flights departing at 19:50, 20:00 or 20:20. You also have the option to do a transit flight via Lima.
Distance & flight times: Mexico City International Airport to Santiago International Airport
The shortest flight time between MEX and SCL is 8 hours and 10 minutes.
Via | Total flight time | Layover time | Distance |
---|---|---|---|
Direct | 8h 10m | - | 4121 miles (6631 km) |
LIM Lima | 10h 55m | 1h 10m | 4190 miles (6742 km) |
BOG Bogota | 12h 15m | 2h 11m | 4630 miles (7450 km) |
CUN Cancun | 12h 55m | 2h 55m | 4731 miles (7612 km) |
PTY Panama City | 13h 56m | 37m | 4510 miles (7257 km) |
EZE Buenos Aires | 22h 25m | 4h 45m | 5332 miles (8579 km) |


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From Mexico City to Chile
Below is a list of other destinations to Chile from Mexico City International Airport with either direct flights or 1 stop connections.
From Mexico to Santiago
Below is a list of other cities in Mexico with flights to Santiago with either non-stop or connecting flights.