Flights from Panama City to Mexico City – Direct & connecting routes
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PTY to NLU – All flight route options from Tocumen International, Panama to Felipe Angeles International Airport, Mexico. These flights are operated by Copa Airlines. You can either fly non-stop to Mexico City or with one stop via TULUM. The shortest flight time is 3 hours and 46 minutes. See the full flight schedule and time table, including departure times, airlines and stopover details to find the best option for you.
Other flight options
Check out these routes. They have daily flights from Tocumen International and connections to Mexico City:
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Panama City to Mexico City flights
This route is operated by 2 airlines. You can fly non-stop to Mexico City (NLU) from Panama City (PTY) with Copa Airlines or opt for a connecting flight via TULUM (TQO).
Panama City to Mexico City with Copa Airlines
You can fly non-stop every Monday, Thursday or Saturday at 09:36. Copa Airlines is a Star Alliance member.
Note Non-stop flights with Copa Airlines will begin in Nov 2025.
Distance & flight times: Tocumen International to Felipe Angeles International Airport
The shortest flight time between PTY and NLU is 3 hours and 46 minutes.
Via | Total flight time | Layover time | Distance |
---|---|---|---|
Direct | 3h 46m | - | 1510 miles (2430 km) |
TQO TULUM | 6h 27m | 1h 45m | 1702 miles (2739 km) |


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From Panama City to Mexico
Below is a list of other destinations to Mexico from Tocumen International with either direct flights or 1 stop connections.
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CUN Cancun Direct
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MEX Mexico City Direct
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MTY Monterrey Direct
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GDL Guadalajara Direct
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SJD San Jose Cabo Direct
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PVR Puerto Vallarta
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TIJ Tijuana
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BJX Leon/Guanajuato
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MZT Mazatlan
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QRO Queretaro