Flights from Panama City to Santa Cruz – Direct & connecting routes
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PTY to VVI – All flight route options from Tocumen International, Panama to Santa Cruz, Bolivia. These routes are operated by 3 airlines. Fly non-stop with BoA or Copa Airlines, or choose from 2 different stopover flights. The shortest flight time is 4 hours and 40 minutes. See the full flight schedule and time table, including departure times, airlines and stopover details to find the best option for you.
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Panama City to Santa Cruz flights
With over 27 flights every week and 4 different airlines you have a wide range of options. You can fly non-stop to Santa Cruz (VVI) from Panama City (PTY) with Copa Airlines or BoA or choose a connecting flight via Bogota (BOG) or Lima (LIM) if it suits you better.
Panama City to Santa Cruz with Copa Airlines
You can fly non-stop every weekday with flights departing at 3:00 pm, 4:00 pm or 9:00 pm. Copa Airlines is a Star Alliance member.
With AVIANCA
If you fly from Panama City with AVIANCA you will do a stopover in Bogota, BOG before reaching Santa Cruz. This flight trip will take 7 hours and 25 minutes and you can fly every weekday with departures at 17:25. AVIANCA is a Star Alliance member.
Distance & flight times: Tocumen International to Santa Cruz
The shortest flight time between PTY and VVI is 4 hours and 56 minutes.
Via | Total flight time | Layover time | Distance |
---|---|---|---|
Direct | 4h 56m | - | 2164 miles (3482 km) |
BOG Bogota | 7h 25m | 1h 55m | 2197 miles (3535 km) |
LIM Lima | 8h 25m | 2h 15m | 2490 miles (4006 km) |


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From Panama City to Bolivia
Below is a list of other destinations to Bolivia from Tocumen International with either direct flights or 1 stop connections.
From Panama to Santa Cruz
We have found another destination to Bolivia from Tocumen International as well.