Flights from Santiago to Medellin – Direct & connecting routes
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SCL to MDE – All flight route options from Arturo Merino Benítez International Airport, Chile to Jose Maria Cordova, Colombia. These flights are operated by 6 airlines. Fly non-stop with JetSMART or choose from 4 different transit flights. The shortest flight time is 6 hours and 20 minutes. See the full flight schedule and time table, including departure times, airlines and stopover details to find the best option for you.
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Santiago to Medellin flights
With over 276 flights every week and 6 different airlines you have a wide range of options. You can fly non-stop to Medellin (MDE) from Santiago (SCL) with JetSMART or AVIANCA but if a stopover option suits you better you can choose to fly via Cali, Lima or any other of the 4 alternatives with connectiing airports.
Santiago to Medellin with JetSMART
You can fly non-stop every Monday, Wednesday, Friday or Sunday with departure times at 07:49 or 08:49. You can also catch a transit flight via Cali or Lima.
Note Non-stop flights with JetSMART will begin in Dec 2025.
With Copa Airlines
If you fly from Santiago with Copa Airlines you will do a stopover in Panama City, PTY before reaching Medellin. This flight trip will take 10 hours and 1 minutes and you can fly every weekday with departures from 4:00 am to 3:00 am. Copa Airlines is a Star Alliance member.
Distance & flight times: Santiago International Airport to Jose Maria Cordova
The shortest flight time between SCL and MDE is 6 hours and 24 minutes.
Via | Total flight time | Layover time | Distance |
---|---|---|---|
Direct | 6h 24m | - | 2770 miles (4457 km) |
CLO Cali | 8h 32m | 2h 8m | 2785 miles (4481 km) |
LIM Lima | 9h 25m | 4h 0m | 2810 miles (4521 km) |
PTY Panama City | 10h 1m | 1h 15m | 3331 miles (5360 km) |
BOG Bogota | 10h 6m | 1h 45m | 2801 miles (4507 km) |


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From Santiago to Colombia
Below is a list of other destinations to Colombia from Arturo Merino Benítez International Airport with either direct flights or 1 stop connections.
From Chile to Medellin
Below is a list of other cities in Chile with flights to Medellin with either non-stop or connecting flights.